Combinatorial Treatment with PARP-1 Inhibitors and Cisplatin Attenuates Cervical Cancer Growth through Fos-Driven Changes in Gene Expression.

Rebecca GupteKen Y LinTulip NanduJayanthi S LeaW Lee Kraus

Published in: Molecular cancer research : MCR (2022)

Our observations, which link the gene regulatory effects of PARPi + cisplatin to the growth inhibitory effects of FOS expression in cervical cancer cells, strengthen the rationale for using PARPi with cisplatin as a therapy for cervical cancer.

Keyphrases

gene expression
poor prognosis
dna repair