The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis.

Rebecca Jane MoonHarry D GreenStefania D'Angelo Keith M Godfrey Justin Huw Davies Elizabeth M Curtis Cyrus Cooper Nicholas C W Harvey

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2023)

There are few RCTs published to address this question, and these are inconsistent in methodology and findings. However, meta-analysis of three trials suggests moderate- to high-dose vitamin D supplementation in pregnancy might increase offspring BMD in early childhood, but further trials are required to confirm this finding. (Prospero CRD42021288682; no funding received).

Keyphrases

bone mineral density
high dose
postmenopausal women
high fat diet
body composition
preterm birth
pregnancy outcomes
low dose
pregnant women
high intensity
stem cell transplantation
adipose tissue
early life
systematic review
insulin resistance
skeletal muscle
randomized controlled trial
metabolic syndrome