Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness.
Timothy D GirardMatthew C ExlineShannon S CarsonCatherine L HoughPeter RockMichelle N GongIvor S DouglasAtul MalhotraRobert L OwensDaniel J FeinsteinBabar KhanMargaret A PisaniRobert C HyzyGregory A SchmidtWilliam D SchweickertR Duncan HiteDavid L BowtonAndrew L MasicaJennifer L ThompsonRameela ChandrasekharBrenda T PunCayce StrengthLeanne M BoehmJames C JacksonPratik P PandharipandeNathan E BrummelChristopher G HughesMayur B PatelJoanna L StollingsGordon R BernardRobert S DittusE Wesley Elynull nullPublished in: The New England journal of medicine (2018)
The use of haloperidol or ziprasidone, as compared with placebo, in patients with acute respiratory failure or shock and hypoactive or hyperactive delirium in the ICU did not significantly alter the duration of delirium. (Funded by the National Institutes of Health and the VA Geriatric Research Education and Clinical Center; MIND-USA ClinicalTrials.gov number, NCT01211522 .).
Keyphrases
- hip fracture
- respiratory failure
- cardiac surgery
- mechanical ventilation
- healthcare
- quality improvement
- extracorporeal membrane oxygenation
- public health
- intensive care unit
- acute kidney injury
- mental health
- acute respiratory distress syndrome
- randomized controlled trial
- health information
- social media
- combination therapy
- human health
- study protocol