Advancements of Porphyrin-Derived Nanomaterials for Antibacterial Photodynamic Therapy and Biofilm Eradication.
Suwen ChenBaoxuan HuangJia TianHongman ZhangPublished in: Advanced healthcare materials (2024)
The threat posed by antibiotic-resistant bacteria and the challenge of biofilm formation has highlighted the inadequacies of conventional antibacterial therapies, leading to increased interest in antibacterial photodynamic therapy (aPDT) in recent years. This approach offers advantages such as minimal invasiveness, low systemic toxicity, and notable effectiveness against drug-resistant bacterial strains. Porphyrins and their derivatives, known for their high molar extinction coefficients and singlet oxygen quantum yields, have emerged as crucial photosensitizers in aPDT. However, their practical application is hindered by challenges such as poor water solubility and aggregation-induced quenching. To address these limitations, extensive research has focused on the development of porphyrin-based nanomaterials for aPDT, enhancing the efficacy of photodynamic sterilization and broadening the range of antimicrobial activity. This review provides an overview of various porphyrin-based nanomaterials utilized in aPDT and biofilm eradication in recent years, including porphyrin-loaded inorganic nanoparticles, porphyrin-based polymer assemblies, supramolecular assemblies, metal-organic frameworks (MOFs), and covalent organic frameworks (COFs). Additionally, insights into the prospects of aPDT is offered, highlighting its potential for practical implementation.
Keyphrases
- photodynamic therapy
- biofilm formation
- metal organic framework
- drug resistant
- pseudomonas aeruginosa
- staphylococcus aureus
- candida albicans
- fluorescence imaging
- escherichia coli
- energy transfer
- multidrug resistant
- acinetobacter baumannii
- silver nanoparticles
- cancer therapy
- cystic fibrosis
- randomized controlled trial
- primary care
- anti inflammatory
- water soluble
- systematic review
- helicobacter pylori infection
- oxidative stress
- molecular dynamics
- essential oil
- quality improvement