A novel synthesized cyclohexane-hydroxytyrosol derivative suppresses ovarian cancer cell growth through inducing ROS and blocking autophagic flux.

ROS plays a critical role in mediating the effects of Chx-HT on proliferation, apoptosis, autophagy, TCA cycle, FAO and mitochondrial respiration, and the autophagic activation underlies the effects of Chx-HT on glycolysis, de novo fatty acid synthesis, and lipid droplet accumulation in ovarian cancer cells. Cotreating OC cells with Chx-HT and autophagic inhibitor or glycolytic inhibitor results in an additive inhibition of proliferation. Our study indicates that Chx-HT stands for a promising OC therapeutic by ROS and autophagy blockade mediated metabolic remodeling.