Silencing the FABP3 gene in insulin-secreting cells reduces fatty acid uptake and protects against lipotoxicity.
Ayman HyderBasma ShetaManar EissaJürgen SchrezenmeirPublished in: Acta diabetologica (2024)
The present data reveals that pancreatic beta cells can be protected from lipotoxicity by inhibition of FA-uptake, intracellular utilization and accumulation. FABP3 inhibition, hence, may be a useful pharmaceutical approach in obesity, metabolic syndrome, and type 2 diabetes.
Keyphrases
- type diabetes
- metabolic syndrome
- induced apoptosis
- insulin resistance
- cell cycle arrest
- fatty acid
- cardiovascular disease
- endoplasmic reticulum stress
- binding protein
- signaling pathway
- skeletal muscle
- gene expression
- cell death
- physical activity
- cell proliferation
- body mass index
- cardiovascular risk factors
- artificial intelligence