Surfactant protein A promotes atherosclerosis through mediating macrophage foam cell formation.
Skylar D KingDunpeng CaiMikayla M FraunfelderShi-You ChenPublished in: bioRxiv : the preprint server for biology (2023)
Our results elucidate that SPA is a novel factor for atherosclerosis development. SPA enhances macrophage foam cell formation and atherosclerosis through increasing scavenger receptor cluster of differentiation antigen 36 (CD36) expression.