Disentangling the Effects of Comorbidity and Polypharmacy on Cognitive Function and Physical Frailty in Individuals with HIV.

Henry Ukachukwu MichaelMarie-Josée BrouilletteRobyn TamblynLesley K FellowsNancy E Mayo

Published in: Journal of acquired immune deficiency syndromes (1999) (2024)

Anticholinergic and sedative burden function as a pathway through which polypharmacy and comorbidities influence physical frailty and perceived cognitive deficits. Reducing the use of anticholinergic and sedative medications could help prevent and manage cognitive impairment and frailty in older people living with HIV.

Keyphrases

community dwelling
physical activity
cognitive impairment
mental health
antiretroviral therapy
hiv infected
human immunodeficiency virus
hiv positive
depressive symptoms
hepatitis c virus
social support
hiv testing
hiv aids
adverse drug
risk factors
emergency department
south africa
drug induced