The effect of hesperetin on estrogen receptor gene expression and its relationship with the downstream pathways of estrogen receptor alpha.

Milad Bideh Samaneh Safari Azam Khedri Mohammad Zangooei

Published in: Molecular biology reports (2023)

The results of our study demonstrate that Hst has the ability to induce cell death in MCF-7 cells. Furthermore, it was observed that Hst reduces the expression of the ER gene and enhances its activity, which can affect the downstream pathways of the ER.

Keyphrases

estrogen receptor
cell death
gene expression
cell cycle arrest
induced apoptosis
poor prognosis
dna methylation
breast cancer cells
genome wide
copy number
endoplasmic reticulum stress
pi k akt
cell proliferation