In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma.
Nicholas T YoungerMollie L WilsonAnabel Martinez LyonsEdward J JarmanAlison M MeynertGraeme R GrimesKonstantinos GournopanosScott H WaddellPeter A TennantDavid H WilsonRachel V GuestStephen J WigmoreJuan Carlos AcostaTimothy James KendallMartin S TaylorDuncan SproulPleasantine MillLuke BoulterPublished in: Cancer research (2022)
This work shows that, despite significant genetic heterogeneity, intrahepatic cholangiocarcinoma relies on a limited number of signaling pathways to grow, suggesting common therapeutic vulnerabilities across patients.