The Dutch chronic lower limb-threatening ischemia registry (THRILLER): A study protocol for popliteal and infrapopliteal endovascular interventions.
Michael J NugterenConstantijn E V B HazenbergGeorge P AkkersdijkOlaf J BakkerMaarten K DinkelmanBram FiooleDaniel A F van den HeuvelJan M M HeyligersJan-Willem HinnenMaurice PierieOlaf SchoutenMichiel A SchreveBart A N VerhoevenGert J de BorstÇağdaş ÜnlüPublished in: PloS one (2023)
Despite innovations in medical therapy and revascularization techniques, patients with CLTI undergoing endovascular revascularization still have a moderate prognosis. Previous prospective cohort studies were hampered by small sample sizes or heterogeneous reporting. Randomized controlled trials (RCTs) have high costs, potential conflicts of interest and give a limited reflection of daily practice. THRILLER aims to provide the largest prospective well phenotyped up-to-date dataset on treatment outcomes in CLTI patients to answer multiple underexplored research questions regarding diagnostics, medication, patient selection, treatment strategies and post intervention follow-up.
Keyphrases
- lower limb
- randomized controlled trial
- healthcare
- end stage renal disease
- physical activity
- chronic kidney disease
- newly diagnosed
- percutaneous coronary intervention
- coronary artery bypass grafting
- primary care
- adverse drug
- prognostic factors
- peritoneal dialysis
- emergency department
- coronary artery disease
- clinical trial
- systematic review
- quality improvement
- patient reported outcomes
- study protocol
- risk assessment
- atrial fibrillation
- smoking cessation
- meta analyses