Autologous Platelet-Rich Plasma Efficacy in the Field of Regenerative Medicine: Product and Quality Control.
Marius Nicolae PopescuMădălina Gabriela IliescuCristina BeiuLiliana Gabriela PopaMara Mădălina MihaiMihai BerteanuAnca Mirela IonescuPublished in: BioMed research international (2021)
Platelet-rich plasma (PRP) has emerged as a significant regenerative therapy used alone or combined mainly with stem cells, autologous fat grafts, hyaluronic acid, and biomaterials in a variety of medical fields, especially in hair regrowth, wound healing, and sports and rehabilitation medicine. However, the results obtained with this biologic therapy are heterogeneous and conflicting. The observed disparities in the effectiveness of PRP therapies may be due to a lack of standardization in blood processing and preparation. This article is aimed at reviewing the main biological parameters that need to be documented for a thorough reporting of quantitative and qualitative characteristics of the PRP injected, to allow a comparison between the quality of samples and the clinically obtained results and advance the efforts towards treatment standardization.
Keyphrases
- platelet rich plasma
- stem cells
- hyaluronic acid
- quality control
- cell therapy
- systematic review
- wound healing
- rheumatoid arthritis
- healthcare
- randomized controlled trial
- quality improvement
- mesenchymal stem cells
- adipose tissue
- tissue engineering
- high resolution
- health insurance
- combination therapy
- adverse drug
- molecularly imprinted
- simultaneous determination