Biological effects of sodium phenylbutyrate and taurursodiol in Alzheimer's disease.

Steven E ArnoldSuzanne HendrixJessie Nicodemus-JohnsonNewman KnowltonVictoria J WilliamsJeffrey M BurnsMonica CraneAlison J McManusSanjeev N VaishnaviZoe ArvanitakisJudith NeugroschlKaren BellBianca A TrombettaBecky C CarlylePia KivisäkkHiroko H DodgeRudolph E TanziPatrick D YeramianKent Leslie

Published in: Alzheimer's & dementia (New York, N. Y.) (2024)

Proteostasis and mitochondrial stress play key roles in Alzheimer's disease (AD).Sodium phenylbutyrate and taurursodiol (PB and TURSO) targets these mechanisms.The PEGASUS trial was designed to assess PB and TURSO effects on biologic AD targets.PB and TURSO reduced exploratory biomarkers of AD and neurodegeneration.Supports further clinical development of PB and TURSO in neurodegenerative diseases.

Keyphrases

heavy metals
aqueous solution
cognitive decline
rheumatoid arthritis
oxidative stress
risk assessment
clinical trial
study protocol
randomized controlled trial
phase ii