Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis.
Sara M BrackettKarlie E CoxSamantha L BarlockWilliam M HugginsDavid F AckartRandall J BassarabaRoberta J MelanderRoberta J MelanderPublished in: RSC medicinal chemistry (2019)
The formation of bacterial biofilms significantly decreases the efficacy of antibiotic treatments. Herein, we've investigated the antibiofilm properties of the natural product meridianin D and a library of analogues against Mycobacterium smegmatis. As a result, we discovered several analogues that both inhibit and disperse M. smegmatis biofilms.