Roberta J Melander (Christian Melander)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 41

Top Topics

Staphylococcus Aureus

Acinetobacter Baumannii

Top Venues

ACS infectious diseases

Chemical biology & drug design

RSC medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Vijay S Gondil, Hailey S Butman, Mikaeel Young, Danica J Walsh, Yogesh Narkhede, Michael J Zeiler, Andrew H Crow, Morgan E Carpenter, Aashay Mardikar, Roberta J Melander, Olaf Wiest, Paul M Dunman, Roberta J Melander
Development of phenyl-urea-based small molecules that target penicillin-binding protein 4. Chemical biology & drug design 103 (6) (2024)
Ansley M Nemeth, Milah M Young, Roberta J Melander, Richard D Smith, Robert K Ernst, Christian Melander
Identification of a 2-Aminobenzimidazole Scaffold that Potentiates Gram-Positive Selective Antibiotics Against Gram-Negative Bacteria. Chembiochem : a European journal of chemical biology 25 (8) (2024)
Haoting Li, Ansley M Nemeth, Roberta J Melander, Roberta J Melander
Synthesis, Stereochemical Resolution, and Analogue Synthesis of Variabiline, an Aporphine Alkaloid That Sensitizes Acinetobacter baumannii and Klebsiella pneumoniae to Colistin. ACS infectious diseases 10 (4) (2024)
Ansley M Nemeth, Milah M Young, Roberta J Melander, Richard D Smith, Robert K Ernst, Christian Melander
Identification of a 2-Aminobenzimidazole Scaffold that Potentiates Gram-Positive Selective Antibiotics Against Gram-Negative Bacteria. Chembiochem : a European journal of chemical biology 25 (8) (2024)
Haoting Li, Ansley M Nemeth, Roberta J Melander, Roberta J Melander
Synthesis, Stereochemical Resolution, and Analogue Synthesis of Variabiline, an Aporphine Alkaloid That Sensitizes Acinetobacter baumannii and Klebsiella pneumoniae to Colistin. ACS infectious diseases 10 (4) (2024)
Ansley M Nemeth, Milah M Young, Roberta J Melander, Richard D Smith, Robert K Ernst, Christian Melander
Identification of a 2-Aminobenzimidazole Scaffold that Potentiates Gram-Positive Selective Antibiotics Against Gram-Negative Bacteria. Chembiochem : a European journal of chemical biology (2024)
Vijay S Gondil, Hailey S Butman, Mikaeel Young, Danica J Walsh, Yogesh Narkhede, Michael J Zeiler, Andrew H Crow, Morgan E Carpenter, Aashay Mardikar, Roberta J Melander, Olaf Wiest, Paul M Dunman, Roberta J Melander
Development of phenyl-urea-based small molecules that target penicillin-binding protein 4. Chemical biology & drug design 103 (6) (2024)
Vijay S Gondil, Hailey S Butman, Mikaeel Young, Danica J Walsh, Yogesh Narkhede, Michael J Zeiler, Andrew H Crow, Morgan E Carpenter, Aashay Mardikar, Roberta J Melander, Olaf Wiest, Paul M Dunman, Roberta J Melander
Development of phenyl-urea-based small molecules that target penicillin-binding protein 4. Chemical biology & drug design 103 (6) (2024)
Ansley M Nemeth, Milah M Young, Roberta J Melander, Richard D Smith, Robert K Ernst, Christian Melander
Identification of a 2-Aminobenzimidazole Scaffold that Potentiates Gram-Positive Selective Antibiotics Against Gram-Negative Bacteria. Chembiochem : a European journal of chemical biology 25 (8) (2024)
Beverly H Koller, Leigh A Jania, Haoting Li, William T Barker, Roberta J Melander, Roberta J Melander
Adjuvants restore colistin sensitivity in mouse models of highly colistin-resistant isolates, limiting bacterial proliferation and dissemination. Antimicrobial agents and chemotherapy (2024)
Haoting Li, Ansley M Nemeth, Roberta J Melander, Roberta J Melander
Synthesis, Stereochemical Resolution, and Analogue Synthesis of Variabiline, an Aporphine Alkaloid That Sensitizes Acinetobacter baumannii and Klebsiella pneumoniae to Colistin. ACS infectious diseases 10 (4) (2024)
Haoting Li, Ansley M Nemeth, Roberta J Melander, Roberta J Melander
Synthesis, Stereochemical Resolution, and Analogue Synthesis of Variabiline, an Aporphine Alkaloid That Sensitizes Acinetobacter baumannii and Klebsiella pneumoniae to Colistin. ACS infectious diseases (2024)
Kenneth I Onyedibe, Ansley M Nemeth, Neetu Dayal, Richard D Smith, Jones Lamptey, Robert K Ernst, Roberta J Melander, Roberta J Melander, Herman O Sintim
Re-sensitization of Multidrug-Resistant and Colistin-Resistant Gram-Negative Bacteria to Colistin by Povarov/Doebner-Derived Compounds. ACS infectious diseases 9 (2) (2023)
Kenneth I Onyedibe, Ansley M Nemeth, Neetu Dayal, Richard D Smith, Jones Lamptey, Robert K Ernst, Roberta J Melander, Roberta J Melander, Herman O Sintim
Re-sensitization of Multidrug-Resistant and Colistin-Resistant Gram-Negative Bacteria to Colistin by Povarov/Doebner-Derived Compounds. ACS infectious diseases 9 (2) (2023)
Kenneth I Onyedibe, Ansley M Nemeth, Neetu Dayal, Richard D Smith, Jones Lamptey, Robert K Ernst, Roberta J Melander, Roberta J Melander, Herman O Sintim
Re-sensitization of Multidrug-Resistant and Colistin-Resistant Gram-Negative Bacteria to Colistin by Povarov/Doebner-Derived Compounds. ACS infectious diseases 9 (2) (2023)
Kenneth I Onyedibe, Ansley M Nemeth, Neetu Dayal, Richard D Smith, Jones Lamptey, Robert K Ernst, Roberta J Melander, Roberta J Melander, Herman O Sintim
Re-sensitization of Multidrug-Resistant and Colistin-Resistant Gram-Negative Bacteria to Colistin by Povarov/Doebner-Derived Compounds. ACS infectious diseases 9 (2) (2023)
Alexander W Weig, Patrick M O'Conner, Jakub M Kwiecinski, Orry M Marciano, Angelica Nunag, Andrew T Gutierrez, Roberta J Melander, Alexander R Horswill, Roberta J Melander
A structure activity relationship study of 3,4'-dimethoxyflavone for ArlRS inhibition in Staphylococcus aureus . Organic & biomolecular chemistry (2023)
Kenneth I Onyedibe, Ansley M Nemeth, Neetu Dayal, Richard D Smith, Jones Lamptey, Robert K Ernst, Roberta J Melander, Roberta J Melander, Herman O Sintim
Re-sensitization of Multidrug-Resistant and Colistin-Resistant Gram-Negative Bacteria to Colistin by Povarov/Doebner-Derived Compounds. ACS infectious diseases (2023)
Kittipan Siwawannapong, Ansley M Nemeth, Roberta J Melander, Jie Rong, Jonathan R Davis, Masahiko Taniguchi, Morgan E Carpenter, Jonathan S Lindsey, Christian Melander
Simple Dipyrrin Analogues of Prodigiosin for Use as Colistin Adjuvants. ChemMedChem 17 (16) (2022)
Haoting Li, Anne E Mattingly, Richard D Smith, Roberta J Melander, Robert K Ernst, Roberta J Melander
6-Bromoindirubin-3'-oxime derivatives are highly active colistin adjuvants against Klebsiella pneumoniae . RSC medicinal chemistry 14 (2) (2022)
Haoting Li, Anne E Mattingly, Richard D Smith, Roberta J Melander, Robert K Ernst, Roberta J Melander
6-Bromoindirubin-3'-oxime derivatives are highly active colistin adjuvants against Klebsiella pneumoniae . RSC medicinal chemistry 14 (2) (2022)
Tonya N Zeczycki, Morgan E Milton, David Jung, Richele J Thompson, Felicia E Jaimes, Alexander D Hondros, Samantha Palethorpe, Roberta J Melander, John Cavanagh
2-Aminoimidazole Analogs Target PhoP Altering DNA Binding Activity and Affect Outer Membrane Stability in Gram-Negative Bacteria. Biochemistry (2022)
Michael J Zeiler, Gina M Connors, Greg M Durling, Allen G Oliver, Lewis Marquez, Roberta J Melander, Cassandra L Quave, Roberta J Melander
Synthesis, Stereochemical Confirmation, and Derivatization of 12(S),16ϵ-Dihydroxycleroda-3,13-dien-15,16-olide, a Clerodane Diterpene That Sensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics. Angewandte Chemie (International ed. in English) 61 (17) (2022)
Haoting Li, Anne E Mattingly, Leigh A Jania, Richard Smith, Roberta J Melander, Robert K Ernst, Beverley H Koller, Roberta J Melander
Benzimidazole Isosteres of Salicylanilides Are Highly Active Colistin Adjuvants. ACS infectious diseases 7 (12) (2021)
Micah Dettweiler, Roberta J Melander, Gina Porras, Caitlin Risener, Lewis Marquez, Tharanga Samarakoon, Roberta J Melander, Cassandra Leah Quave
A Clerodane Diterpene from Callicarpa americana Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics. ACS infectious diseases 6 (7) (2020)
Alexander W Weig, Samantha L Barlock, Patrick M O'Connor, Orry M Marciano, Richard Smith, Robert K Ernst, Roberta J Melander, Roberta J Melander
A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors. RSC medicinal chemistry 12 (2) (2020)
William T Barker, Leigh A Jania, Roberta J Melander, Beverly H Koller, Roberta J Melander
Eukaryotic phosphatase inhibitors enhance colistin efficacy in gram-negative bacteria. Chemical biology & drug design 96 (5) (2020)
Michael J Zeiler, Roberta J Melander, Christian Melander
Second-Generation Meridianin Analogues Inhibit the Formation of Mycobacterium smegmatis Biofilms and Sensitize Polymyxin-Resistant Gram-Negative Bacteria to Colistin. ChemMedChem 15 (17) (2020)
Anne E Mattingly, Karlie E Cox, Richard Smith, Roberta J Melander, Robert K Ernst, Roberta J Melander
Screening an Established Natural Product Library Identifies Secondary Metabolites That Potentiate Conventional Antibiotics. ACS infectious diseases 6 (10) (2020)
Karlie E Cox, Roberta J Melander
Anti-biofilm activity of quinazoline derivatives against Mycobacterium smegmatis. MedChemComm 10 (7) (2019)
Sara E Martin, Roberta J Melander, Christopher M Brackett, Alison J Scott, Courtney E Chandler, Catherine M Nguyen, Bradley M Minrovic, Sarah E Harrill, Robert K Ernst, Colin Manoil, Roberta J Melander
Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii. ACS infectious diseases 5 (7) (2019)
Ansley M Nemeth, Akash K Basak, Alexander W Weig, Santiana A Marrujo, William T Barker, Leigh A Jania, Tyler A Hendricks, Ashley E Sullivan, Patrick M O'Connor, Roberta J Melander, Beverly H Koller, Christian Melander
Structure-Function Studies on IMD-0354 Identifies Highly Active Colistin Adjuvants. ChemMedChem 15 (2) (2019)
T Vu Nguyen, Matthew T Peszko, Roberta J Melander, Roberta J Melander
Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation. MedChemComm 10 (3) (2019)
William T Barker, Ansley M Nemeth, Sara M Brackett, Akash K Basak, Courtney E Chandler, Leigh A Jania, William J Zuercher, Roberta J Melander, Beverly H Koller, Robert K Ernst, Roberta J Melander
Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-Negative Bacteria. ACS infectious diseases 5 (10) (2019)
Sara M Brackett, Karlie E Cox, Samantha L Barlock, William M Huggins, David F Ackart, Randall J Bassaraba, Roberta J Melander, Roberta J Melander
Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis. RSC medicinal chemistry 11 (1) (2019)
T Vu Nguyen, Bradley M Minrovic, Roberta J Melander, Roberta J Melander
Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold. ChemMedChem 14 (9) (2019)
Veronica B Hubble, Brittany A Hubbard, Bradley M Minrovic, Roberta J Melander, Roberta J Melander
Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa. ACS infectious diseases 5 (1) (2018)
William M Huggins, T Vu Nguyen, Nicholas A Hahn, James T Baker, Laura G Kuo, Darpan Kaur, Roberta J Melander, John S Gunn, Roberta J Melander
2-Aminobenzimidazoles as antibiofilm agents against Salmonella enterica serovar Typhimurium. MedChemComm 9 (9) (2018)
Sara E Martin, Catherine M Nguyen, Randall J Basaraba, Roberta J Melander
Analogue synthesis reveals decoupling of antibiofilm and β-lactam potentiation activities of a lead 2-aminoimidazole adjuvant against Mycobacterium smegmatis. Chemical biology & drug design 92 (2) (2018)
Bradley M Minrovic, David Jung, Roberta J Melander, Roberta J Melander
New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumannii. ACS infectious diseases 4 (9) (2018)
Rose Byrne-Nash, Danielle M Lucero, Niki A Osbaugh, Roberta J Melander, Roberta J Melander, Daniel L Feldheim
Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered through Small Molecule Variable Ligand Display. Bioconjugate chemistry 28 (7) (2017)