Lyso-Gb3 Increases αvβ3 Integrin Gene Expression in Cultured Human Podocytes in Fabry Nephropathy.

Hernán TrimarchiAlberto Ortiz Arduan Maria Dolores Sánchez-Niño

Published in: Journal of clinical medicine (2020)

Human podocyte stress in response to glycolipid overload in Fabry nephropathy, exemplified by lyso-Gb3, is characterized by an early increase in the expression of components of the αvβ3/UPAR system, which contrasts with the delayed rise in the expression of other mediators of podocyte injury. This suggests that the αvβ3/UPAR system may be a therapeutic target in Fabry nephropathy.

Keyphrases

endothelial cells
high glucose
gene expression
poor prognosis
replacement therapy
diabetic nephropathy
hypertrophic cardiomyopathy
induced pluripotent stem cells
binding protein