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Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose.

Chenyan ZhaoAnna ChirkovaStaffan RosenborgRodrigo Palma VillarJohan LindbergSven N HobbieLena E Friberg
Published in: The Journal of antimicrobial chemotherapy (2022)
The results support further Phase II clinical trials with apramycin at an anticipated efficacious dose of 30 mg/kg once daily.
Keyphrases
  • phase ii
  • clinical trial
  • open label
  • phase iii
  • double blind
  • big data
  • physical activity
  • study protocol
  • randomized controlled trial
  • machine learning