Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer.

Ru-Hong Tu Sheng-Ze Wu Chang-Ming Huang Qing Zhong Yin-Hua Ye Chao-Hui Zheng Jian-Wei Xie Jia-Bin Wang Jian-Xian Lin Qi-Yue Chen Chang-Ming Huang Mi Lin Jun Lu Long-Long Cao Ping Li

Published in: Cancer research (2023)

Nerve cancer cross-talk mediated by HTR2B inhibits lipid peroxidation and ferroptosis in gastric cancer cells and promotes viability under metabolic stress, resulting in increased tumor growth and decreased patient survival.

Keyphrases

cell death
papillary thyroid
fatty acid
squamous cell
case report
squamous cell carcinoma
peripheral nerve
stress induced
free survival
childhood cancer
heat stress