Aging Is Associated With Organ-Specific Alterations in the Level and Expression Pattern of von Willebrand Factor.
Parnian AlaviRadya Yousef AbduallaDouglas W BrownAnahita MojiriJayan NagendranJohn D LewisStephane L BourqueNadia JahroudiPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Aging elicits a heterogenic response in endothelial cells with regard to VWF expression, leading to organ-specific increase in VWF levels and alterations in vascular tree pattern of expression. This is concomitant with increased platelet aggregate formation. The age-associated increase in VWF expression may be modulated through the process of cell senescence, and p53 transcription factor contributes to its regulation.