Enhancement of the GluN2B subunit of glutamatergic NMDA receptors in rat brain areas after cocaine abstinence.

Irena SmagaKarolina WydraAgata SuderMarek SanakLucia CaffinoFabio FumagalliMałgorzata Filip

Published in: Journal of psychopharmacology (Oxford, England) (2021)

In summary, in this study we showed region-specific changes in both the expression of GluN2B subunit and NMDA receptor trafficking during cocaine abstinence under different housing conditions. Furthermore, we showed that the pharmacological blockade of the GluN2B subunit may be useful in attenuating cocaine-seeking behavior.

Keyphrases

smoking cessation
protein kinase
poor prognosis
prefrontal cortex
mental health
mental illness
long non coding rna