Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome.

Ruoyang ZhaiWoodys Lenga Ma BondaCharlotte LeclaireCécile Saint-BéatCamille TheilliereCorinne BelvilleRandy CoupetRaiko BlondonnetDamien BouvierLoic BlanchonVincent SapinMatthieu Jabaudon

Published in: Journal of translational medicine (2023)

Sevoflurane decreased injury and restored epithelial barrier function in two in vivo and in vitro models of sterile lung injury, which was associated with increased expression of junction proteins and decreased actin cytoskeletal rearrangement. In vitro findings suggest that sevoflurane may decrease lung epithelial permeability through the RhoA/pMLC/F-actin pathway.

Keyphrases

acute respiratory distress syndrome
extracorporeal membrane oxygenation
mechanical ventilation
endothelial cells
poor prognosis
long non coding rna
binding protein
intensive care unit