In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations.

Wilhelmus E A de WitteJoost W VersfeltMaria KuzikovSolene RollandVictoria GeorgiPhilip GribbonSheraz GulDymphy HuntjensPiet Hein van der GraafMeindert DanhofAmaury E Fernández-MontalvánGesa WittElizabeth C M De Lange

Published in: British journal of pharmacology (2018)

Signal transduction and feedback are important determinants of the time course of drug effects. The effect of the D2 receptor antagonist dissociation rate constant (koff ) is limited to the maximal rate of fluctuations in dopamine signalling as determined by the dopamine koff and the cAMP turnover.

Keyphrases

uric acid
prefrontal cortex
binding protein
metabolic syndrome
molecular docking
bone mineral density
resistance training
protein kinase
adverse drug
body composition
drug induced