Polygenic prediction of PTSD trajectories in 9/11 responders.
Monika A WaszczukAnna R DochertyAndrey A ShabalinJiaju MiaoXiaohua YangPei-Fen KuanEvelyn BrometRoman KotovBenjamin J LuftPublished in: Psychological medicine (2020)
Psychiatric PRSs prospectively predicted WTC-related PTSD lifetime diagnosis, average symptom severity, and 18-year trajectory in responders to 9/11 disaster. Jointly, PRSs were more predictive of subsequent PTSD than the exposure severity. In the future, PRSs may help identify at-risk responders who might benefit from targeted prevention approaches.