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Polygenic prediction of PTSD trajectories in 9/11 responders.

Monika A WaszczukAnna R DochertyAndrey A ShabalinJiaju MiaoXiaohua YangPei-Fen KuanEvelyn BrometRoman KotovBenjamin J Luft
Published in: Psychological medicine (2020)
Psychiatric PRSs prospectively predicted WTC-related PTSD lifetime diagnosis, average symptom severity, and 18-year trajectory in responders to 9/11 disaster. Jointly, PRSs were more predictive of subsequent PTSD than the exposure severity. In the future, PRSs may help identify at-risk responders who might benefit from targeted prevention approaches.
Keyphrases
  • posttraumatic stress disorder
  • social support
  • depressive symptoms
  • mental health
  • current status