Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.
Jari M T LahtiSamuli T TuominenQiong YangGiulio PergolaShahzad AhmadNajaf AminNicola J ArmstrongAlexa BeiserKatharina BeyJoshua C BisEric BoerwinkleJan BresslerArchie I CampbellHarry CampbellQiang ChenJanie CorleySimon R CoxGail DaviesPhilip Lawrence De JagerEske M DerksJessica D FaulAnnette L FitzpatrickAlison E FohnerIan FordMyriam FornageZachary F GerringHans Jörgen GrabeFrancine GrodsteinVilmundur GudnasonEleanor SimonsickElizabeth G HollidayPeter K JoshiEero KajantieJaakko A KaprioPauliina KarellLuca KleineidamMaria J KnolNicole A KochanJohn B KwokMarkus LeberMax LamTeresa LeeShuo LiAnu LoukolaTobias LuckRiccardo E MarioniKaren A MatherSarah E MedlandSaira S MirzaMike A NallsKwangsik NhoAdrienne O'DonnellChristopher OldmeadowJodie N PainterAlison PattieSimone ReppermundShannon L RisacherRichard J RoseVijay SadashivaiahMarkus ScholzClaudia L SatizabalPeter W SchofieldKatharina E SchrautRodney J ScottJeannette SiminoAlbert V SmithJennifer A SmithDavid J StottIda SurakkaAlexander TeumerAnbupalam ThalamuthuStella TrompetStephen T TurnerSven J van der LeeArno VillringerLinus VölkerRobert S WilsonKatharina WittfeldEero VuoksimaaRui XiaKristine YaffeLei YuHabil ZareWei ZhaoDavid AmesJohn Richard AttiaDavid A BennettHenry BrodatyDaniel I ChasmanAaron L GoldmanCaroline HaywardMohammad Arfan IkramJohan Wouter JukemaSharon L R KardiaTodd LenczMarkus LoefflerVenkata S MattayAarno PalotieBruce M PsatyAlfredo RamirezPaul M RidkerSteffi G Riedel-HellerPerminder Singh SachdevAndrew J SaykinMartin SchererPeter R SchofieldStephen SidneyJohn M StarrJulian N TrollorWilliam UlrichMichael WagnerDavid R WeirJames F WilsonMargaret J WrightDaniel R WeinbergerStephanie DebetteJohan G ErikssonThomas H MosleyLenore J LaunerCornelia M Van DuijnIan J DearySudha SeshadriKatri RäikkönenPublished in: Molecular psychiatry (2022)
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
Keyphrases
- working memory
- genome wide
- copy number
- dna methylation
- transcranial direct current stimulation
- attention deficit hyperactivity disorder
- meta analyses
- genome wide association study
- systematic review
- randomized controlled trial
- atrial fibrillation
- metabolic syndrome
- white matter
- multiple sclerosis
- bipolar disorder
- skeletal muscle
- cognitive decline
- brain injury