A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases.

Annalisa AddanteWilfred RaymondIrina GitlinAnnabelle CharbitXavier OrainAaron Wolfe SchefflerAditi KuppeJulia DuerrMaria DaniltchenkoMarika DrescherSimon Y GraeberAnne-Marie HealyStefan OscarsonJohn V FahyMarcus Alexander Mall

Published in: The European respiratory journal (2023)

MUC-031 is a potent and fast acting mucolytic that decreases airway mucus plugging, lessens airway inflammation, and improves survival in βENaC-Tg mice. These data provide rationale for human trials of MUC-031 in muco-obstructive lung diseases.

Keyphrases

endothelial cells
electronic health record
clinical trial
big data
pluripotent stem cells
adipose tissue
replacement therapy
insulin resistance
free survival