Single-cell transcriptome analysis of lineage diversity in high-grade glioma.

Jinzhou YuanHanna Mendes LevitinVeronique FrattiniErin C BushDeborah M BoyettJorge SamanamudMichele CeccarelliAthanassios DovasGeorge ZanazziPeter CanollJeffrey N BruceAnna LasorellaAntonio IavaronePeter A Sims

Published in: Genome medicine (2018)

These studies reveal a relationship between cellular identity and proliferation in HGG and distinct population structures that reflects the extent of neural and non-neural lineage resemblance among malignantly transformed cells.

Keyphrases

single cell
high grade
rna seq
induced apoptosis
high throughput
signaling pathway
low grade
cell cycle arrest
mass spectrometry
case control
cell fate
pi k akt