The epidermal growth factor receptor variant type III mutation frequently found in gliomas induces astrogenesis in human cerebral organoids.
Hyun-Mun KimSang-Hyeok LeeJaejoon LimJongman YooDong-Youn HwangPublished in: Cell proliferation (2020)
EGFRvIII mutation-induced astrogenesis and massive cell proliferation in a human brain development model. These results provide us new insights into the mechanisms relating EGFRvIII mutation-mediated gliogenesis and gliomagenesis.