Differences in social brain function in autism spectrum disorder are linked to the serotonin transporter: A randomised placebo-controlled single-dose crossover trial.
Nichol M L WongOttavia DipasqualeFederico TurkheimerJames L FindonRobert H WichersMihail DimitrovClodagh M MurphyVladimira StoenchevaDene M RobertsonDeclan G MurphyEileen DalyGrainne M McAlonanPublished in: Journal of psychopharmacology (Oxford, England) (2022)
Our findings suggest that the SERT-enriched functional network is dynamically different in ASD during processing of socially relevant stimuli. Whether this acute neurobiological response to citalopram in ASD translates to a clinical target will be an important next step.
Keyphrases
- autism spectrum disorder
- placebo controlled
- phase iii
- double blind
- phase ii
- study protocol
- open label
- clinical trial
- intellectual disability
- attention deficit hyperactivity disorder
- liver failure
- phase ii study
- healthcare
- resting state
- randomized controlled trial
- respiratory failure
- white matter
- mental health
- drug induced
- aortic dissection
- functional connectivity
- hepatitis b virus
- intensive care unit
- subarachnoid hemorrhage