Attainment of Low Disease Activity and Remission Targets reduces the risk of severe flare and new damage in Childhood Lupus.
Eve Mary Dorothy SmithKukatharmini TharmaratnamEslam Al-AbadiKate ArmonKathryn BaileyMary BrennanCoziana CiurtinJanet Gardner-MedwinKirsty E HaslamDaniel HawleyAlice LeahyValentina LeoneGulshan MalikZoe McLarenClarissa PilkingtonAthimalaipet V RamananSatyapal RangarajAnnie RatcliffePhilip RileyEthan SenArani SridharNick WilkinsonChristian M HedrichAndrea JorgensenMichael W BeresfordPublished in: Rheumatology (Oxford, England) (2021)
This is the first study demonstrating that adult-SLE-derived definitions of LDA/remission are achievable in cSLE, significantly reducing risk of severe flare/new damage. Of the LDA definitions, LLDAS performed best, leading to a statistically comparable reduction in the hazards of severe flare to attainment of clinical-remission.