The Challenges of Cortisol Replacement Therapy in Childhood: Observations from a Case Series of Children Treated with Modified-Release Hydrocortisone.
Julie ParkUrmi DasMohammed DidiRenuka RamakrishnanMatthew PeakPaul NewlandJoanne C BlairPublished in: Paediatric drugs (2019)
Smoother cortisol profiles and more sustained cortisol exposure were achieved during treatment with Plenadren, which was the preferred treatment in most patients. Robust clinical trials are required to determine the place of this medication in paediatric practice.
Keyphrases
- replacement therapy
- clinical trial
- end stage renal disease
- newly diagnosed
- healthcare
- ejection fraction
- chronic kidney disease
- primary care
- intensive care unit
- young adults
- smoking cessation
- emergency department
- peritoneal dialysis
- prognostic factors
- randomized controlled trial
- patient reported outcomes
- quality improvement
- combination therapy
- childhood cancer
- drug induced