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SOFA and mortality endpoints in randomized controlled trials: a systematic review and meta-regression analysis.

Harm-Jan S de GroothIrma L GeenenArmand R GirbesJean-Louis VincentJean-Jacques ParientiHeleen M Oudemans-van Straaten
Published in: Critical care (London, England) (2017)
Treatment effects on Delta SOFA appear to be reliably and consistently associated with mortality in RCTs. Fixed-day SOFA was the most frequently reported outcome among the reviewed RCTs, but was not significantly associated with mortality. Based on this study, we recommend using Delta SOFA rather than Fixed-day SOFA as an endpoint in future RCTs.
Keyphrases
  • cardiovascular events
  • randomized controlled trial
  • risk factors
  • cardiovascular disease
  • type diabetes
  • coronary artery disease
  • current status
  • smoking cessation