Human embryonic stem cell-derived neural crest model unveils CD55 as a cancer stem cell regulator for therapeutic targeting in MYCN-amplified neuroblastoma.

Zhihui WengJiacheng LinJiaozi HeLin GaoSien LinLai Ling TsangHang ZhangXiaoyan HeGuang WangXuesong YangHu ZhouHui ZhaoGang LiLin ZouXiaohua Jiang

Published in: Neuro-oncology (2021)

MYCN shapes CD55 into a novel cancer stem cell regulator which represents a prognostic marker and therapeutic target of MNA-NB. The hESC-derived NC model serves as a valuable platform for investigating NB initiation and progression and developing potential therapeutic targets.

Keyphrases

cancer stem cells
stem cells
endothelial cells
transcription factor
high throughput
nk cells
induced pluripotent stem cells
bone marrow
pluripotent stem cells
human health