Antibiotic Exposure Does Not Impact Immune Checkpoint Blockade Response in MSI-H/dMMR Metastatic Colorectal Cancer: A Single-Center Experience.
Victoria Serpas HigbieJane E RogersHyunsoo HwangWei QiaoLianchun XiaoArvind N DasariKerri Mola-RuddVan Karlyle MorrisRobert A WolffKanwal P S RaghavRyan HueyChristine M ParseghianJason A WillisEdmund S KopetzMichael James OvermanBenny JohnsonPublished in: The oncologist (2022)
Our data show no association of lower response rates or survival in those MSI-H/dMMR patients with mCRC who receive antibiotics around the initiation of ICB. This information needs to be confirmed in a larger prospective cohort.