The risk of hospitalized infection following initiation of biologic agents versus methotrexate in the treatment of juvenile idiopathic arthritis.

Timothy BeukelmanFenglong XieJohn W BaddleyLang ChenMelissa L MannionKenneth G SaagJie ZhangJeffrey R Curtis

Published in: Arthritis research & therapy (2016)

Neither TNFi monotherapy nor TNFi + MTX combination therapy was significantly associated with hospitalized infection compared with MTX. Anakinra was significantly associated with infection, but there was likely residual confounding by disease phenotype.

Keyphrases

combination therapy
juvenile idiopathic arthritis
rheumatoid arthritis
clinical trial
randomized controlled trial
low dose
study protocol