The Role of Epigenetics in Neuroinflammatory-Driven Diseases.
Sebastiano GiallongoLucia LonghitanoSimona DenaroSimona D'AprileFilippo TorrisiEnrico La SpinaCesarina GiallongoGiuliana ManninoDebora Lo FurnoAgata ZappalàRosario GiuffridaRosalba ParentiGiovanni Li VoltiDaniele TibulloNunzio VicarioPublished in: International journal of molecular sciences (2022)
Neurodegenerative disorders are characterized by the progressive loss of central and/or peripheral nervous system neurons. Within this context, neuroinflammation comes up as one of the main factors linked to neurodegeneration progression. In fact, neuroinflammation has been recognized as an outstanding factor for Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and multiple sclerosis (MS). Interestingly, neuroinflammatory diseases are characterized by dramatic changes in the epigenetic profile, which might provide novel prognostic and therapeutic factors towards neuroinflammatory treatment. Deep changes in DNA and histone methylation, along with histone acetylation and altered non-coding RNA expression, have been reported at the onset of inflammatory diseases. The aim of this work is to review the current knowledge on this field.
Keyphrases
- multiple sclerosis
- amyotrophic lateral sclerosis
- dna methylation
- traumatic brain injury
- poor prognosis
- healthcare
- lipopolysaccharide induced
- genome wide
- lps induced
- gene expression
- cognitive impairment
- white matter
- mass spectrometry
- oxidative stress
- spinal cord
- circulating tumor
- cognitive decline
- cerebral ischemia
- inflammatory response
- binding protein
- ms ms
- cell free
- histone deacetylase
- subarachnoid hemorrhage
- combination therapy
- blood brain barrier