Dose-Dependent Proton Pump Inhibitor Exposure and Risk of Type 2 Diabetes: A Nationwide Nested Case-Control Study.

Hsin-Ya KuoChih-Sung Liang Shih-Jen Tsai Yun-Ting Chang Che-Sheng ChuMu-Hong Chen

Published in: International journal of environmental research and public health (2022)

A dose-dependent increased risk of T2DM was found among patients with UGID using higher doses of PPIs compared with those with lower doses of these drugs. Further studies are necessary to investigate the underlying pathophysiology of PPIs and T2DM.

Keyphrases

type diabetes
glycemic control
case control
cardiovascular disease
insulin resistance
cross sectional
drug induced