Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response.

Amy L NagelbergTianna S SihotaYu-Chi ChuangRocky ShiJustine L M ChowJohn EnglishCalum MacAulayStephen LamWan L Lam William W Lockwood

Published in: British journal of cancer (2024)

These data suggest that SHPRH is a tumor suppressor gene in LUAD, whereby its expression is associated with more favorable patient outcomes, reduced tumor and mutational burden, and may serve as a predictor of response to DNA damage. Thus, further exploration into the role of SHPRH in LUAD development may make it a valuable biomarker for predicting LUAD risk and prognosis.

Keyphrases

dna damage response
dna damage
genome wide
dna repair
copy number
poor prognosis
genome wide identification
oxidative stress
dna methylation
big data
binding protein
risk factors
machine learning
long non coding rna
gene expression
deep learning