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[Leptin and leptin receptor evaluation in atherosclerotic plaques in patients with type 2 diabetes mellitus].

Diana Arshaluysovna DimitrovaIlya MikhailovK Y TokarevM S MichurovaA M GorbachevaNatalia V DanilovaP G MalkovV Y Kalashnikov
Published in: Terapevticheskii arkhiv (2021)
Based on the expression of CD68, -SMA, CD34, leptin receptor and leptin, no significant differences were observed in atherosclerotic plaque between patients with and without DM. At the same time, despite the limitations of the study (a small number of patients, moderate severity of DM, elderly patients in the DM group), we found a tendency in the increased number of leptin receptors and a decreased number of -SMA+, CD68+ in DM atherosclerotic plaques. Further study needed, taking into account the limitations of this work.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • chronic kidney disease
  • coronary artery disease
  • poor prognosis
  • nk cells
  • high intensity
  • adipose tissue
  • insulin resistance
  • patient reported outcomes
  • weight loss