Talaromides A-C, Bioactive Cyclic Heptapeptides from Talaromyces siglerae Isolated from a Marine Sponge.
Youbin ChoKyu-Hyung ParkEunhee KimSeungjin KimWeihong WangHyukjae ChoiHeonjoong KangPublished in: Journal of natural products (2024)
Three new cyclic heptapeptides, talaromides A-C ( 1 - 3 ), were isolated from cultures produced by the fungus Talaromyces siglerae (Ascomycota), isolated from an unidentified sponge. The structures, featuring an unusual proline-anthranilic moiety, were elucidated by analysis of spectroscopic data and chemical transformations, including the advanced Marfey's method and GITC derivatization. Talaromides A and B inhibited migration activity against PANC-1 human pancreatic cancer cells without significant cytotoxicity.
Keyphrases
- endothelial cells
- molecular docking
- ms ms
- induced pluripotent stem cells
- electronic health record
- liquid chromatography tandem mass spectrometry
- high performance liquid chromatography
- pluripotent stem cells
- gas chromatography mass spectrometry
- high resolution
- big data
- simultaneous determination
- liquid chromatography
- tandem mass spectrometry
- machine learning
- mass spectrometry
- solid phase extraction