Four Decades of Laccase Research for Wastewater Treatment: Insights from Bibliometric Analysis.

Increasing trends of environmental pollution and emerging contaminants from anthropogenic activities have urged researchers to develop innovative strategies in wastewater management, including those using the biocatalyst laccase (EC 1.10.3.2). Laccase works effectively against a variety of substrates ranging from phenolic to non-phenolic compounds which only require molecular oxygen to be later reduced to H 2 O as the final product. In this study, we performed a bibliometric analysis on the metadata of literature acquired through the Scopus database (24 October 2022) with keyword combination "Laccase" AND "Pollutant" OR "Wastewater". The included publications were filtered based on year of publication (1978-2022), types of articles (original research articles and review articles) and language (English). The metadata was then exported in a CSV (.csv) file and visualized on VosViewer software. A total of 1865 publications were identified, 90.9% of which were original research articles and the remaining 9.1% were review articles. Most of the authors were from China ( n = 416; 22.3%) and India ( n = 276; 14.79%). In the case of subject area, 'Environmental Science' emerged with the highest published documents ( n = 1053; 56.46%). The identified papers mostly cover laccase activity in degrading pollutants, and chitosan, which can be exploited for the immobilization. We encourage more research on laccase-assisted wastewater treatment, especially in terms of collaborations among organizations.