Remote sp2 C-H Carboxylation via Catalytic 1,4-Ni Migration with CO2.

Marino BörjessonDaniel Janssen-MüllerBasudev SahooYaya DuanXueqiang WangRúben Martín

Published in: Journal of the American Chemical Society (2020)

A remote catalytic reductive sp2 C-H carboxylation of arenes with CO2 (1 bar) via 1,4-Ni migration is disclosed. This protocol constitutes the first catalytic 1,4-Ni migration reported to date, thus offering new vistas in the Ni-catalyzed reductive coupling arena while providing an unconventional new platform for incorporating electrophilic sites at remote sp2 C-H linkages.

Keyphrases

metal organic framework
transition metal
room temperature
randomized controlled trial
crystal structure
high throughput
single cell
ionic liquid