Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss.
Aaron JesuthasanSviatlana ZhyzhneuskayaCarl PetersAlison C BarnesKieren G HollingsworthNaveed SattarMichael Ernest John LeanRoy TaylorAhmad H Al-MrabehPublished in: Diabetologia (2021)
In type 2 diabetes, women have liver and pancreas fat levels as high as those of men, associated with raised hepatic VLDL1-TG production rates. Dynamics of triacylglycerol turnover differ between sexes in type 2 diabetes and following weight loss. These changes may contribute to the disproportionately raised cardiovascular risk of women with diabetes.
Keyphrases
- type diabetes
- weight loss
- glycemic control
- bariatric surgery
- adipose tissue
- roux en y gastric bypass
- cardiovascular disease
- fatty acid
- gastric bypass
- insulin resistance
- polycystic ovary syndrome
- bone mineral density
- weight gain
- rheumatoid arthritis
- body mass index
- disease activity
- pregnant women
- obese patients
- body composition
- metabolic syndrome
- systemic lupus erythematosus
- postmenopausal women
- breast cancer risk