Two by Two Factorial Design using Metformin and Curcumin for Second Primary Head and Neck Cancer Prevention Trial.
Vikram KekatpureNarayana SubramaniamSumsum SunnySruthi NambiarTinku SarahVaishnav VasudevanAnusha RaoAnupama MuraliTrupti KolurArvind KrishnamurthyRajesh KanthariaSudhir V NairKrishnakumar ThankappanBaruah M NRajeev KumarSatheesan BalasubramanianRajendra TopraniSunil AgrawalaAzar Jan BattooJaimanti BakshiSajith BabuSiddharth ShahNiravkumar TrivediSumithra SelvamRavi KannanArun KumarAmritha SureshVijay PillaiPankaj ChaturvediSubramania IyerMoni Abraham KuriakosePublished in: Asian Pacific journal of cancer prevention : APJCP (2024)
2x2 factorial design is an effective trial design for chemoprevention clinical trials where the effectiveness of multiple interventions needs to be tested parallelly.