Quantitative evaluation of factors influencing the 3 Hz repetitive nerve stimulation test in patients with amyotrophic lateral sclerosis.

Jinghong ZhangFei YangMao LiYahui ZhuXusheng Huang

Published in: Muscle & nerve (2024)

In patients with ALS, NMJ safety factor is reduced during re-innervation. Decremental response is affected by multiple factors, which needs to be considered in clinical trials targeting the NMJ in these patients.

Keyphrases

amyotrophic lateral sclerosis
clinical trial
newly diagnosed
ejection fraction
high frequency
prognostic factors
randomized controlled trial
patient reported outcomes
drug delivery
open label