Systemic treatments in the management of atopic dermatitis: A systematic review and meta-analysis.
Doreen SiegelsAnnice HeratizadehSusanne AbrahamJonas BinnmyrKnut BrockowAlan D IrvineSusanne HalkenCharlotte Gotthard MortzCarsten FlohrPeter Schmid-GrendlmeierLauri-Ann Van der PoelAntonella MuraroStephan WeidingerThomas WerfelJochen Schmittnull nullPublished in: Allergy (2020)
The most robust, replicated high-quality trial evidence is present for the efficacy and safety of dupilumab for up to 1 year in adults. Robust trial evidence was further revealed for AZA, baricitinib and CSA. Methodological restrictions led to limited evidence-based conclusions for all other systemic treatments. Head-to-head trials with novel systemic treatments are required to clarify the future role of conventional therapies.