Allopurinol Use and the Risk of Type 2 Diabetes Mellitus: A Meta-Analysis of Cohort Studies.

Shih-Wei LaiBing-Fang HwangYu-Hung KuoChiu-Shong LiuKuan-Fu Liao

Published in: Dose-response : a publication of International Hormesis Society (2022)

The meta-analysis shows that no correlation is detected between allopurinol use and the risk of T2DM in individuals with gout and/or hyperuricemia. Because there are not enough eligible studies, the strength of evidence in our meta-analysis is weak. More cohort studies are needed to determine an association between use of allopurinol and the probability of T2DM for individuals with gout and/or hyperuricemia.

Keyphrases

systematic review
uric acid
case control
meta analyses
metabolic syndrome
randomized controlled trial
type diabetes
insulin resistance
weight loss