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[New targets for the prevention and treatment of cirrhotic portal vein thrombosis].

Y W WangH G Ding
Published in: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (2024)
Portal vein thrombosis (PVT) is divided into cirrhotic and non-cirrhotic PVTs. The incidence rate of PVT varies greatly among different clinical stages of cirrhosis, with an overall incidence rate of about 13.92%, and the prevalence of cirrhotic PVT following splenectomy is as high as 60%. The pathogenesis of cirrhotic PVT is still unclear. However, the activation of Janus kinase/signal transduction and activator transcription signaling pathways, the rise in the expression of von Willebrand factor, and the gut microbiota along with its metabolite trimethylamine-N-oxide play an important role in the injury of vascular endothelial cells and the formation of PVT in cirrhosis. Therefore, these could be a new target for cirrhotic PVT prevention and treatment.
Keyphrases
  • risk factors
  • endothelial cells
  • pulmonary embolism
  • signaling pathway
  • poor prognosis
  • combination therapy
  • long non coding rna
  • cell proliferation
  • protein kinase
  • smoking cessation