Modeling of clinical phenotypes in systemic lupus erythematosus based on the platelet transcriptome and FCGR2a genotype.

MacIntosh G CornwellHanane El BannoudiElliot Luttrell-WilliamsAlexis EngelTessa J BarrettKhrystyna MyndzarPeter IzmirlyH Michael BelmontRobert ClancyKelly V RugglesJill P BuyonJeffrey S Berger

Published in: Journal of translational medicine (2023)

In aggregate, these data demonstrate the platelet transcriptome provides insight into lupus pathogenesis and disease activity, and shows potential use as means of assessing this complex disease using a liquid biopsy.

Keyphrases

disease activity
systemic lupus erythematosus
rheumatoid arthritis
rheumatoid arthritis patients
rna seq
single cell
ankylosing spondylitis
genome wide
juvenile idiopathic arthritis
gene expression
electronic health record
big data
ultrasound guided
artificial intelligence