Transfer of mesenchymal stem cell mitochondria to CD4 + T cells contributes to repress Th1 differentiation by downregulating T-bet expression.

Waseem AkhterJean NakhleLoïc VaillantGeneviève GarcinCécile Le SaoutMatthieu SimonCarole CrozetFarida DjouadChristian JorgensenMarie-Luce VignaisJavier Hernandez

Published in: Stem cell research & therapy (2023)

T cells results in the suppression of Th1 responses in part by downregulating T-bet expression. Furthermore, our studies suggest that MSC mitochondrial transfer might represent a general mechanism of MSC-dependent immunosuppression.

Keyphrases

poor prognosis
mesenchymal stem cells
oxidative stress
binding protein
long non coding rna
cell death
stem cells
reactive oxygen species