IL-17-induced inflammation modulates the mPGES-1/PPAR-γ pathway in monocytes/macrophages.

Federica RaucciAnella SavianoGian Marco CasilloMiguel Guerra-RodriguezAdel Abo MansourMarialuisa PiccoloMaria Grazia FerraroElisabetta PanzaValentina VelleccoCarlo IraceFrancesco CasoRaffaele ScarpaNicola MascoloMohammed AlfaifiAsif Jilani Iqbal Francesco Maione

Published in: British journal of pharmacology (2021)

Our data suggest that IL-17 may constitute a specific modulator of inflammatory monocytes during later phases of the inflammatory response. The results of this study show, for the first time, that the IL-17/mPGES-1/PPAR-γ pathway could represent a potential therapeutic target for inflammatory-based and immune-mediated diseases.

Keyphrases

oxidative stress
inflammatory response
insulin resistance
diabetic rats
dendritic cells
peripheral blood
electronic health record
high glucose
lipopolysaccharide induced
machine learning
fatty acid
endothelial cells
toll like receptor
risk assessment
adipose tissue
drug induced
immune response
skeletal muscle