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IL-17-induced inflammation modulates the mPGES-1/PPAR-γ pathway in monocytes/macrophages.

Federica RaucciAnella SavianoGian Marco CasilloMiguel Guerra-RodriguezAdel Abo MansourMarialuisa PiccoloMaria Grazia FerraroElisabetta PanzaValentina VelleccoCarlo IraceFrancesco CasoRaffaele ScarpaNicola MascoloMohammed AlfaifiAsif Jilani IqbalFrancesco Maione
Published in: British journal of pharmacology (2021)
Our data suggest that IL-17 may constitute a specific modulator of inflammatory monocytes during later phases of the inflammatory response. The results of this study show, for the first time, that the IL-17/mPGES-1/PPAR-γ pathway could represent a potential therapeutic target for inflammatory-based and immune-mediated diseases.
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